You are here: OMIA / Search / OMIA:000344 / golden hamster

OMIA:000344-10036 : Epilepsy in Mesocricetus auratus (golden hamster)

In other species: chicken , white-tufted-ear marmoset , dog , domestic cat , horse , taurine cattle , rabbit , Mongolian gerbil , prairie vole

Categories: Behaviour / neurological phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 104130 (trait) , 117100 (trait) , 121200 (trait) , 121201 (trait) , 125370 (trait) , 132090 (trait) , 132100 (trait) , 132300 (trait) , 159600 (trait) , 182610 (trait) , 203600 (trait) , 208700 (trait) , 220300 (trait) , 226750 (trait) , 226800 (trait) , 226810 (trait) , 226850 (trait) , 254770 (trait) , 254780 (trait) , 254800 (trait) , 266270 (trait) , 267740 (trait) , 270805 (trait) , 301900 (trait) , 310370 (trait) , 545000 (trait) , 600131 (trait) , 600143 (trait) , 600512 (trait) , 600513 (trait) , 600669 (trait) , 601068 (trait) , 245570 (trait)

Single-gene trait/disorder: no

Mode of inheritance: Multifactorial

Disease-related: yes

Key variant known: no

History: As summarised by Muñoz et al. (2017): "The hamster has been previously described as a paroxysmal dystonia model, but our strain is currently recognized as a model of audiogenic seizures (AGS). The original first epileptic hamster appeared spontaneously at the University of Valladolid, where it was known as the GPG:Vall line, and was transferred to the University of Salamanca where a new strain was developed, named GASH:Sal."

Markers: Díaz-Casado et al. (2020) "performed whole exome sequencing (WES) in GASH/Sal animals and their corresponding controls to identify and characterize the mutational landscape of the GASH/Sal strain . . . [from which] 3 high-impact and 15 moderate-impact variants were identified", thereby providing strong evidence of the mutifactorial nature of this disorder. Díaz-Rodríguez et al. (2023) "addressed the influence of the missense single-nucleotide polymorphism (C9586732T, p.His289Tyr) in the glutamate receptor ionotropic kainate-1 (Grik1) gene and its implications for the GASH/Sal seizure susceptibility. ... [The] study reinforces the substantial body of evidence implicating GluK1 receptors in the mechanisms underlying seizures."

Contact us

If you notice anything missing or in need of change, please contact us at: [email protected].

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:000344-10036: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Bonet-Fernández, J.M., Tranque, P., Aroca-Aguilar, J.D., Muñoz, L.J., López, D.E., Escribano, J., de Cabo, C. :
Seizures regulate the cation-Cl<sup>-</sup> cotransporter NKCC1 in a hamster model of epilepsy: implications for GABA neurotransmission. Front Neurol 14:1207616, 2023. Pubmed reference: 37448751. DOI: 10.3389/fneur.2023.1207616.
Díaz-Rodríguez, S.M., Herrero-Turrión, M.J., García-Peral, C., Gómez-Nieto, R. :
Delving into the significance of the His289Tyr single-nucleotide polymorphism in the glutamate ionotropic receptor kainate-1 (Grik1) gene of a genetically audiogenic seizure model. Front Mol Neurosci 16:1322750, 2023. Pubmed reference: 38249292. DOI: 10.3389/fnmol.2023.1322750.
García-Peral, C., Ledesma, M.M., Herrero-Turrión, M.J., Gómez-Nieto, R., Castellano, O., López, D.E. :
Proteomic and bioinformatic tools to identify potential hub proteins in the audiogenic seizure-prone hamster GASH/Sal. Diagnostics (Basel) 13:1048, 2023. Pubmed reference: 36980356. DOI: 10.3390/diagnostics13061048.
2021 Fuerte-Hortigón, A., Gonçalves, J., Zeballos, L., Masa, R., Gómez-Nieto, R., López, D.E. :
Distribution of the Cannabinoid Receptor Type 1 in the Brain of the Genetically Audiogenic Seizure-Prone Hamster GASH/Sal. Front Behav Neurosci 15:613798, 2021. Pubmed reference: 33841106. DOI: 10.3389/fnbeh.2021.613798.
2020 Díaz-Casado, E., Gómez-Nieto, R., de Pereda, J.M., Muñoz, L.J., Jara-Acevedo, M., López, D.E. :
Analysis of gene variants in the GASH/Sal model of epilepsy. PLoS One 15:e0229953, 2020. Pubmed reference: 32168507. DOI: 10.1371/journal.pone.0229953.
Díaz-Rodríguez, S.M., López-López, D., Herrero-Turrión, M.J., Gómez-Nieto, R., Canal-Alonso, A., Lopéz, D.E. :
Inferior Colliculus Transcriptome After Status Epilepticus in the Genetically Audiogenic Seizure-Prone Hamster GASH/Sal. Front Neurosci 14:508, 2020. Pubmed reference: 32528245. DOI: 10.3389/fnins.2020.00508.
Sánchez-Benito, D., Hyppolito, M.A., Alvarez-Morujo, A.J., López, D.E., Gómez-Nieto, R. :
Morphological and molecular correlates of altered hearing sensitivity in the genetically audiogenic seizure-prone hamster GASH/Sal. Hear Res 392:107973, 2020. Pubmed reference: 32402894. DOI: 10.1016/j.heares.2020.107973.
2017 Barrera-Bailón, B., Oliveira, J.A.C., López, D.E., Muñoz, L.J., Garcia-Cairasco, N., Sancho, C. :
Pharmacological and neuroethological study of the acute and chronic effects of lamotrigine in the genetic audiogenic seizure hamster (GASH:Sal). Epilepsy Behav 71:207-217, 2017. Pubmed reference: 26876275. DOI: 10.1016/j.yebeh.2015.11.005.
López-López, D., Gómez-Nieto, R., Herrero-Turrión, M.J., García-Cairasco, N., Sánchez-Benito, D., Ludeña, M.D., López, D.E. :
Overexpression of the immediate-early genes Egr1, Egr2, and Egr3 in two strains of rodents susceptible to audiogenic seizures. Epilepsy Behav 71:226-237, 2017. Pubmed reference: 26775236. DOI: 10.1016/j.yebeh.2015.12.020.
Muñoz, L.J., Carballosa-Gautam, M.M., Yanowsky, K., García-Atarés, N., López, D.E. :
The genetic audiogenic seizure hamster from Salamanca: The GASH:Sal. Epilepsy Behav 71:181-192, 2017. Pubmed reference: 27072920. DOI: 10.1016/j.yebeh.2016.03.002.
Prieto-Martín, A.I., Aroca-Aguilar, J.D., Sánchez-Sánchez, F., Muñoz, L.J., López, D.E., Escribano, J., de Cabo, C. :
Molecular and neurochemical substrates of the audiogenic seizure strains: The GASH:Sal model. Epilepsy Behav 71:218-225, 2017. Pubmed reference: 26071997. DOI: 10.1016/j.yebeh.2015.05.025.
Sánchez-Benito, D., Gómez-Nieto, R., Hernández-Noriega, S., Murashima, A.A.B., de Oliveira, J.A.C., Garcia-Cairasco, N., López, D.E., Hyppolito, M.A. :
Morphofunctional alterations in the olivocochlear efferent system of the genetic audiogenic seizure-prone hamster GASH:Sal. Epilepsy Behav 71:193-206, 2017. Pubmed reference: 27492627. DOI: 10.1016/j.yebeh.2016.05.040.
2013 Barrera-Bailón, B., Oliveira, J.A., López, D.E., Muñoz, L.J., Garcia-Cairasco, N., Sancho, C. :
Pharmacological and neuroethological studies of three antiepileptic drugs in the Genetic Audiogenic Seizure Hamster (GASH:Sal). Epilepsy Behav 28:413-25, 2013. Pubmed reference: 23872084. DOI: 10.1016/j.yebeh.2013.05.028.
Carballosa-Gonzalez, M.M., Muñoz, L.J., López-Alburquerque, T., Pardal-Fernández, J.M., Nava, E., de Cabo, C., Sancho, C., López, D.E. :
EEG characterization of audiogenic seizures in the hamster strain GASH:Sal. Epilepsy Res 106:318-25, 2013. Pubmed reference: 23916142. DOI: 10.1016/j.eplepsyres.2013.07.001.
2012 Prieto-Martín, A.I., Llorens, S., Pardal-Fernández, J.M., Muñoz, L.J., López, D.E., Escribano, J., Nava, E., de Cabo, C. :
Opposite caudal versus rostral brain nitric oxide synthase response to generalized seizures in a novel rodent model of reflex epilepsy. Life Sci 90:531-7, 2012. Pubmed reference: 22326500. DOI: 10.1016/j.lfs.2012.01.010.
2008 Fuentes-Santamaría, V., Alvarado, J.C., Herranz, A.S., García-Atarés, N., López, D.E. :
Decreased levels of GABA in the inferior colliculus of the epilepsy-prone hamster (GPG/Vall). Epilepsy Res 79:224-7, 2008. Pubmed reference: 18372163. DOI: 10.1016/j.eplepsyres.2008.02.003.
2007 Fuentes-Santamaría, V., Alvarado, J.C., Herranz, A.S., García-Atarés, N., López, D.E. :
Morphologic and neurochemical alterations in the superior colliculus of the genetically epilepsy-prone hamster (GPG/Vall). Epilepsy Res 75:206-19, 2007. Pubmed reference: 17628427. DOI: 10.1016/j.eplepsyres.2007.06.005.
2005 Fuentes-Santamaría, V., Cantos, R., Alvarado, J.C., García-Atarés, N., López, D.E. :
Morphologic and neurochemical abnormalities in the auditory brainstem of the genetically epilepsy-prone hamster (GPG/Vall). Epilepsia 46:1027-45, 2005. Pubmed reference: 16026555. DOI: 10.1111/j.1528-1167.2005.68104.x.

Edit History


  • Created by Frank Nicholas on 31 Oct 2016
  • Changed by Frank Nicholas on 15 Mar 2020
  • Changed by Imke Tammen2 on 23 Jan 2024