OMIA:001617-9694 : Sweet taste, lack of in Panthera tigris (tiger)

In other species: domestic cat , cheetah

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 606226 (gene)

Single-gene trait/disorder: yes

Disease-related: yes

Key variant known: yes

Year key variant first reported: 2005

Cross-species summary: By sequencing very likely candidate genes (i.e. "genes involved in the initial transduction of sweet perception [which] might account for the indifference to sweet-tasting foods by cats"), Li et al. (2005) provided convincing evidence that one of the two genes required for the heteromer T1R2/T1R3 sweet-taste receptor, namely TAS1R2, is a non-functional pseudogene in all cats, tigers and cheetahs: in these species, the TAS1R2 gene has "a 247-base pair microdeletion in exon 3 and stop codons in exons 4 and 6" (Li et al., 2005). The authors argued that it seems likely that this same pseudogene may exist in all felidae.

Associated gene:

Symbol	Description	Species	Chr	Location	OMIA gene details page	Other Links
TAS1R2		Panthera tigris	C1	NC_056667.1 (13540364..13522337)	TAS1R2	Ensembl, NCBI gene

Variants

By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.

WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.

OMIA Variant ID	Breed(s)	Variant Phenotype	Gene	Allele	Variant Type	Variant Effect	Source of Genetic Variant	Pathogenicity Classification*	Reference Sequence	Chr.	g. or m.	c. or n.	p.	Verbal Description	EVA ID	Year Published	PubMed ID(s)	Acknowledgements

OMIA Variant ID	Breed(s)	Variant Phenotype	Gene	Allele	Variant Type	Variant Effect	Source of Genetic Variant	Pathogenicity Classification*	Reference Sequence	Chr.	g. or m.	c. or n.	p.	Verbal Description	EVA ID	Year Published	PubMed ID(s)	Acknowledgements
670		Sweet taste, lack	TAS1R2		deletion, gross (>20)		Naturally occurring variant	Not currently ISAG evaluated						"a 247-base pair microdeletion in exon 3 and stop codons in exons 4 and 6"		2005	16103917

* Variant pathogenicity for single gene diseases as evaluated by an expert panel of the International Society of Animal Genetics (ISAG) Animal Genetic Testing Standardization Standing Committee

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Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2012). OMIA:001617-9694: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2006

Li, X., Li, W., Wang, H., Bayley, D.L., Cao, J., Reed, D.R., Bachmanov, A.A., Huang, L., Legrand-Defretin, V., Beauchamp, G.K., Brand, J.G. :

Cats lack a sweet taste receptor. J Nutr 136:1932S-1934S, 2006. Pubmed reference: 16772462.

2005

Li, X., Li, W., Wang, H., Cao, J., Maehashi, K., Huang, L., Bachmanov, A.A., Reed, D.R., Legrand-Defretin, V., Beauchamp, G.K., Brand, J.G. :

Pseudogenization of a sweet-receptor gene accounts for cats' indifference toward sugar. PLoS Genet 1:27-35, 2005. Pubmed reference: 16103917. DOI: 10.1371/journal.pgen.0010003.

Edit History

Created by Frank Nicholas on 04 Oct 2011
Changed by Frank Nicholas on 22 Mar 2012