OMIA:001956-9031 : Resistance/susceptibility to avian sarcoma and leukosis viruses, subgroup J in Gallus gallus (chicken) |
Categories: Immune system phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 107310 (gene)
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal recessive
Disease-related: yes
Key variant known: yes
Year key variant first reported: 2020
Species-specific description: Chai and Bates (2006) identified the receptor for subgroup J viruses as being the Na+/H+ exchanger type 1 (chNHE1).
Molecular basis: Using "precise CRISPR/Cas9 gene editing", Koslová et al. (2020) deleted the triplet for the critical receptor amino acid (W38) in the chNHE1 gene that encodes functional receptor for subgroup J leukosis virus, creating ΔW38. The authors reported that "The resistance to ALV-J was examined both in vitro and in vivo, and the ΔW38 homozygous chickens tested ALV-J-resistant, in contrast to ΔW38 heterozygotes and wild-type birds, which were ALV-J-susceptible. Deletion of W38 did not manifest any visible side effect."
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | Gallus gallus | 23 | NC_052554.1 (2256836..2237984) | SLC9A1 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001956-9031: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2022 | Mo, G., Hu, B., Zhang, Q., Ruan, Z., Li, W., Liang, J., Shen, Y., Mo, Z., Zhang, Z., Wu, Z., Shi, M., Zhang, X. : |
| dPRLR causes differences in immune responses between early and late feathering chickens after ALV-J infection. Vet Res 53:1, 2022. Pubmed reference: 34998433. DOI: 10.1186/s13567-021-01016-7. | |
| 2021 | Kheimar, A., Klinger, R., Bertzbach, L.D., Sid, H., Yu, Y., Conradie, A.M., Schade, B., Böhm, B., Preisinger, R., Nair, V., Kaufer, B.B., Schusser, B. : |
| A genetically engineered commercial chicken line is resistant to highly pathogenic avian leukosis virus subgroup J. Microorganisms 9:1066, 2021. Pubmed reference: 34069313. DOI: 10.3390/microorganisms9051066. | |
| 2020 | Hellmich, R, Sid, H, Lengyel, K, Flisikowski, K, Schlickenrieder, A, Bartsch, D, Thoma, T, Bertzbach, LD, Kaufer, BB, Nair, V, Preisinger, R, Schusser, B : |
| Acquiring resistance against a retroviral infection via CRISPR/Cas9 targeted genome editing in a commercial chicken line Front. Genome Ed. 2:3, 2020. DOI: https://doi.org/10.3389/fgeed.2020.00003. | |
| Koslová, A., Trefil, P., Mucksová, J., Reinišová, M., Plachý, J., Kalina, J., Kučerová, D., Geryk, J., Krchlíková, V., Lejčková, B., Hejnar, J. : | |
| Precise CRISPR/Cas9 editing of the NHE1 gene renders chickens resistant to the J subgroup of avian leukosis virus. Proc Natl Acad Sci U S A 117:2108-2112, 2020. Pubmed reference: 31964810. DOI: 10.1073/pnas.1913827117. | |
| 2018 | Guan, X., Zhang, Y., Yu, M., Ren, C., Gao, Y., Yun, B., Liu, Y., Wang, Y., Qi, X., Liu, C., Cui, H., Zhang, Y., Gao, L., Li, K., Pan, Q., Zhang, B., Wang, X., Gao, Y. : |
| Residues 28 to 39 of the Extracellular Loop 1 of Chicken Na<sup>+</sup>/H<sup>+</sup> Exchanger Type I Mediate Cell Binding and Entry of Subgroup J Avian Leukosis Virus. J Virol 92:e01627-17, 2018. Pubmed reference: 29070685. DOI: 10.1128/JVI.01627-17. | |
| 2016 | Reinišová, M., Plachý, J., Kučerová, D., Šenigl, F., Vinkler, M., Hejnar, J. : |
| Genetic Diversity of NHE1, Receptor for Subgroup J Avian Leukosis Virus, in Domestic Chicken and Wild Anseriform Species. PLoS One 11:e0150589, 2016. Pubmed reference: 26978658. DOI: 10.1371/journal.pone.0150589. | |
| 2013 | Cai, L.M., Wang, Z.Z., Wang, Y.M., Shen, Y.w., Wei, R.R., Cheng, Z.Q. : |
| [The relationship of virus load, receptor expression and tumor spectrum in layer chickens infected by ALV-J]. Bing Du Xue Bao 29:515-21, 2013. Pubmed reference: 24386840. | |
| Kucerová, D., Plachy, J., Reinisová, M., Senigl, F., Trejbalová, K., Geryk, J., Hejnar, J. : | |
| Nonconserved tryptophan 38 of the cell surface receptor for subgroup J avian leukosis virus discriminates sensitive from resistant avian species. J Virol 87:8399-407, 2013. Pubmed reference: 23698309. DOI: 10.1128/JVI.03180-12. | |
| 2006 | Chai, N., Bates, P. : |
| Na+/H+ exchanger type 1 is a receptor for pathogenic subgroup J avian leukosis virus. Proc Natl Acad Sci U S A 103:5531-6, 2006. Pubmed reference: 16567631. DOI: 10.1073/pnas.0509785103. |
Edit History
- Created by Frank Nicholas on 27 Apr 2015
- Changed by Frank Nicholas on 27 Apr 2015
- Changed by Frank Nicholas on 24 Jan 2020
- Changed by Frank Nicholas on 15 May 2020
- Changed by Imke Tammen2 on 10 Jun 2021
- Changed by Imke Tammen2 on 30 Jan 2022
- Changed by Imke Tammen2 on 16 Oct 2023