OMIA:002237-8090 : Coat colour, few melanophore in Oryzias latipes (Japanese medaka) |
Categories: Pigmentation phene
Single-gene trait/disorder: yes
Mode of inheritance: Autosomal recessive
Disease-related: no
Key variant known: yes
Year key variant first reported: 2020
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| kitlga | Oryzias latipes | 6 | NC_019864.2 (2512710..2469124) | kitlga | Ensembl, NCBI gene |
Variants
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
| OMIA Variant ID | Breed(s) | Variant Phenotype | Gene | Allele | Variant Type | Variant Effect | Source of Genetic Variant | Pathogenicity Classification* | Reference Sequence | Chr. | g. or m. | c. or n. | p. | Verbal Description | EVA ID | Year Published | PubMed ID(s) | Acknowledgements |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1152 | Few melanophore | kitlga | insertion, gross (>20) | Naturally occurring variant | Not currently ISAG evaluated | Otsuki et al. (2020): "the phenotype of fm medaka is attributable to insertion of a Tcb1-like transposon at the kitlga locus" | 2020 | 31757930 |
* Variant pathogenicity for single gene diseases as evaluated by an expert panel of the International Society of Animal Genetics (ISAG) Animal Genetic Testing Standardization Standing Committee
Contact us
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Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2020). OMIA:002237-8090: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2023 | Wagatsuma, T., Suzuki, E., Shiotsu, M., Sogo, A., Nishito, Y., Ando, H., Hashimoto, H., Petris, M.J., Kinoshita, M., Kambe, T. : |
| Pigmentation and TYRP1 expression are mediated by zinc through the early secretory pathway-resident ZNT proteins. Commun Biol 6:403, 2023. Pubmed reference: 37072620. DOI: 10.1038/s42003-023-04640-5. | |
| 2020 | Otsuki, Y., Okuda, Y., Naruse, K., Saya, H. : |
| Identification of kit-ligand a as the gene responsible for the medaka pigment cell mutant few melanophore. G3 (Bethesda) 10:311-9, 2020. Pubmed reference: 31757930. DOI: 10.1534/g3.119.400561. |
Edit History
- Created by Frank Nicholas on 30 Jan 2020
- Changed by Frank Nicholas on 30 Jan 2020